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In line with this, mice with an -cell specific knock-down of PC1/3, resulting in significantly reduced islet GLP-1 content, were able to maintain normal glucose tolerance, suggesting that islet GLP-1 may not be essential and/or that it can be compensated for by intestinally derived GLP-1 under normal conditions
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Louis (Part I) Jun 3, 2023 7 min read Dr
2020;11:e00178
Options include orlistat (for BMI 28 kg/m with risk factors or 30 kg/m) and, where specific criteria are met, GLP-1 receptor agonists such as semaglutide or liraglutide
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